The existence of mammals and reptilia with a natural resistance to snake venoms is known since a long time. This fact has been subjected to the study by several research workers. Our experiments showed us that in the marsupial Didelphis marsupialis, a mammal highly resistant to the venom of Bothrops jararaca, and other Bothrops venoms, has a genetically origin protein, a alpha-1, acid glycoprotein, now highly purified, with protective action in mice against the jararaca snake venom.

Neste trabalho descrevemos experiencias destinadas a mostrar a influência do pH nas crises convulsivas por resfriamento da medula espinhal da rã e estudar o mecanismo da ação inibidora do gás carbonico sobre estas conculsões. Verificamos que o CO² não age atravez um abaixamento do pH do sangue ou do meio intercelular. O gás carbonico teria uma ação específica que estaria ligada á sua grande difusibilidade. Essa sua propriedade permitiria que penetrasse ràpidamente no interior de neurônio, abaixando sensìvelmente o pH intracelular, sem que houvesse nítida variação do pH do sangue.

In this work described experiments to show the influence of the pH on convulsions caused by cooling the spinal cord of frogs, and to study the mechanism of the inhibitory action of carbon dioxide on these convulsions. We found that carbon dioxide does not act by lowering the pH of the blood or intercellular medium. Carbon dioxide would have a specific action which would be connected with its great diffusibility. This property would enable it to penetrate rapidly into the interior of the neurone, appreciably lowering the intracellular pH, in the absence of a clear variation in the pH of the blood.